Abstract
δ-Aminolevulinic acid (ALA) synthetase activities in the range of 0.1 to 100 U/ml of enzyme are routinely assayed using a modified Beckman Model 121 amino acid analyzer. THis method reproducibly and specifically quantitates [ 14C]aminolevulinate from a mixture of [ 14C]succinate metabolites known to interfere in other methods. Mitochondrial ALA synthetase activity in livers of normal adult guinea pigs is determined to be approximately 3 U/g of liver. This activity is only 1 100 th the activity in guinea pigs treated with the porphyrinogenic drug 3,5-dicarbethoxy-1,4-dihydrocollidine.
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