Abstract
To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma. A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma. The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up. Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma.
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