Abstract
I desire to ask your indulgence for departing from the more customary annual review of current surgical progress and to invite your attention to a subject of so narrow a scope as the caption of this paper sets forth. Long considered safe from invasion by the most daring surgeon, both because of its almost inaccessible position and because of its intimate relation to life, the question of its feasibility to surgical attack has been answered in the affirmative. The question has now changed to, When, and how shall one operate? Embraced within the brief period of twenty years, beginning with Marie's demonstration of the definite relationship of pituitary disease to acromegaly (1889) and ending with the memorable paper of Harvey Cushing read before this Section three years ago, all the knowledge of this subject has been accumulated. Were new arguments in proof of the value of scientific animal experimental research
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