Abstract
AbstractWe examined a method for the preparation of 4‐hydroxypyran‐2‐ones in two steps from aryl ketones and ethyl malonyl chloride (or ethyl 2‐methylmalonyl chloride). These 4‐hydroxypyran‐2‐ones are useful precursors as they may be transformed in two steps to the 2‐methoxypyran‐4‐ones, which is found in phenoxan—a naturally occurring compound discovered to have anti‐HIV activity.
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