An approach to physiologically meaningful distributed inverse solutions to the neuro-electromagnetic inverse problem

Abstract

The problem of determining generators of brain electromagnetic activity has no unique solution. The only way to deal this problem, sometimes denominated the problem of non-uniqueness, is to restrict set of possible solutions by using either physiological or mathematical constraints or a combination of both. The main purpose of this work is to propose a method for obtaining a unique distributed solution to neuro-electromagnetic inverse problem by considering physiological constraints regarding spatio temporal distribution of generators. We will focus in discussing distributed inverse solutions (given in terms of current density vector) which are general enough to include concentrated inverse solution. Aspects related to uniqueness of new inverse solution proposed are discussed that suggest that this solution warrants further development. We consider as main merit of this proposal possibility of including new terms extracted from new developments in neurophysiology.