An approach to Improve Therapeutic Efficacy of Doxycycline Hyclate in Treatment of Periodontitis.

Abstract

A number of ways have been investigated for administration of antibacterial agents in dealing withplaque-initiated periodontal disease. These include prolonged release intrapocket devices which are inserted at diseased sites. Intrapocket drug delivery system was designed which contain Doxycycline Hyclate; an antibacterial agent. The formulations were so developed with an aim to reduce the dose of a drug, to target the drug to the specific site and to maintain dosage at its absorption site for an extended period of time thereby improves the patient compliance. The study was aimed towards by formulating the periodontal in situ gels by temperature induced gelation technique with the utilization of polymer Pluronic F127 which is synthetically prepared. The Pluronic F127 showed the sol-gel transition phenomenon in between 27-37 °C. In situ gels were prepared and characterized/evaluated for its physico-chemical properties such as pH, gelation properties, rheology, gel strength, mucoadhesion, drug content, in-vitro, and ex-vivo drug release rate, texture analysis and Differential Scanning Colorimetry etc. The formulation found to be solution at room temperature and forms gel after installation into periodontal pocket hence leadingto increase in retention time and to slowly release the drug into pocket. The results of characterization of formulation were found to be satisfactory and hence significant bioavailability can be increased, so these in situ gelling systems will be useful in future for improving therapeutic efficacy of Doxycycline hyclate in treatment of Periodontitis. Owing to these properties it can be used as an effective delivery system for the intrapocket route.