An approach to implement virtual channels for flowing magnetic beads

Abstract

This work demonstrates the feasibility of a novel microfluidic system with virtual channels formed by ‘walls’ of magnetic fields, including collecting channels, transporting channels and function channels. The channels are defined by the nickel patterns. With its own ferromagnetism, nickel can be magnetized using an external magnetic field; the nickel structures then generate magnetic fields that can either guide or trap magnetic beads. A glass substrate is sandwiched between the liquid containing magnetic beads and the chip with nickel structures, preventing the liquid from directly contacting the nickel. In this work, collecting channels, transporting channels and function channels are displayed sequentially. In the collecting channel portion, channels with different shapes are compared. Next, in the transporting channel portion we demonstrate I-, S- and Y-shaped channels can steer magnetic beads smoothly. Finally, in the function channel portion, a switchable trapping channel implemented with a bistable mechanism performs the passing and blocking of a magnetic bead.