An Approach to Evaluate Anti-arthritic and Thrombolytic Activity of Different parts of Solanum torvum Sw. (Solanaceae) and Smilax zeylanica L. (Liliaceae)

Abstract

Phytochemical screening of chloroform and methanolic extracts of different parts of Solanum torvum and Smilax zeylanica was done. In vitro thrombolytic and anti-arthritic activities were assessed using the clot lysis method and egg albumin denaturation technique respectively. Between the chloroform and methanolic extracts, Chloroform extracts of both plants showed higher clot lysis activities (at 100 ppm solution). On the other hand, extracts of both plants performed better in terms of anti-arthritic activities (at 500 ppm solution). In the case of thrombolytic activity, between the plant extracts, the performance of S. torvum is higher compared to S. zeylanica plant. Among chloroform extracts of different plant parts, stem of S. torvum and root of S. zeylanica showed the highest, 35.44±1.89 % and 33.63±0.83 % activities respectively. Whereas, among the methanolic extracts of the plants, the root extracts of both plants showed the highest activities, 31.96±2.86 % for S. torvum and 32.01±1.46 % for S. zeylanica. In the case of anti-arthritic activity, the performance of S. zeylanica plant extracts is higher compared to that of S. torvum. Methanolic extract of leaf of S. zeylanica samples showed the best protein denaturation activity (52.38±2.12 %) followed by the Methanolic extract of stem sample of S. torvum (44.29±2.14 %).