Abstract
Determination of 24 free amino acid levels of plasma by ion-exchange chromatography, accuracy 2-5%. In maternal hypertention and maternal nutritional deprivation there are high foetal levels of alanine, glycine and proline and a resistance to the rapid decline normally seen neonatally. The findings are in agreement with the assumption of decreased gluconeogenesis from amino acids in foetal deprivation. The glycine/valine ratio can discriminate between small size at birth due to low post-menstrual age and low birth weight and crown-heel length in relation to post-menstrual age in maternal hypertention and in low socio-economic groups with maternal nutritional deprivation. The glycine/valine ratio is suggested as a valid parameter in the subclassification of the different anthropometric groups of newborn babies prior to clinical investigation.
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