Abstract
RECQ1 is the most abundant member of the human RecQ family of DNA helicases genetically linked with cancer predisposition syndromes and well known for their functions in genome stability maintenance through DNA repair. Despite being the first discovered RecQ homolog in humans, biological functions of RECQ1 have remained largely underappreciated and its relevance to cellular transformation is yet unclear. RECQ1 is overexpressed and amplified in many clinical cancer samples. In silico evaluation of RECQ1 mRNA expression across the NCI-60 cancer cell lines predicts an association of RECQ1 with cancer cell migration, invasion, and metastasis. Consistent with this, latest work implicates RECQ1 in regulation of gene expression, especially of those associated with cancer progression. Functionally, silencing RECQ1 expression significantly reduces cell proliferation, migration, and invasion. Collectively, these results propose that discerning the role of RECQ1 in conferring proliferative and invasive phenotype to cancer cells could be useful in developing therapeutic strategies to block primary tumor progression and metastasis.
Highlights
The RecQ helicase family is a group of highly conserved DNA unwinding enzymes described as caretakers of the genome (Hickson, 2003; Brosh, 2013; Croteau et al, 2014)
RECQ1, known as RECQL or RECQL1, is the most abundant member of the RecQ helicase family represented by five homologs: RECQ1, WRN, BLM, RECQL4, and RECQL5 (Sharma and Brosh, 2008)
Using the CellMiner NCI-60 analysis tools, we searched for genes that were significantly correlated with RECQ1-expression across the NCI-60 panel and had established functions in cell migration and invasion (Figure 2A)
Summary
The RecQ helicase family is a group of highly conserved DNA unwinding enzymes described as caretakers of the genome (Hickson, 2003; Brosh, 2013; Croteau et al, 2014). RECQ1 EXPRESSION ACROSS THE NCI-60 HUMAN TUMOR CELL LINES By virtue of its overexpression in cancer and its association with cell proliferation, migration, and invasion, RECQ1 can potentially serve as a predictive biomarker and attractive target for cancer therapy.
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