An Application of Corona-Treated and Chemically Modified Poly(D-Lactic Acid) Films as Benzydamine Hydrochloride Carriers

Abstract

In the present article, chitosan and casein polyelectrolyte multilayers (PEMs) deposited on poly(D-lactic acid) (PDLA) substrates are investigated. PDLA substrates are modified both physically under negative corona discharge and chemically with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> -ethyl- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N ^\prime $ </tex-math></inline-formula> -(3-dimethylaminopropyl) carbodiimide hydrochloride (EDAC). The substrates modified by a combination of corona discharge and chemical modification are also studied. The topology of the multilayers is studied with AFM. The electret properties of the substrates obtained are investigated. The dependencies of the normalized surface potential on the storage time are studied. A layer-by-layer (LbL) deposition technique is used for multilayer deposition on the substrates. PEMs with eight layers are obtained. Benzydamine hydrochloride (Benz) is immobilized in the resulting PEMs. Drug loading efficiency and drug release from PDLA multilayers are studied. The results of PDLA multilayers demonstrate that the chemical modification of the PDLA substrates increases the amount of Benz loaded in the multilayers. The combination of corona treatment and chemical modification results in lower amounts of loaded drugs in both combination cases, when compared with only chemically modified samples.