Abstract
An apparatus for the study of migration of a solute from its solution in a non-aqueous solvent into the walls of soft shell capsules is described. The solution is applied to the top of a glycerogelatin column contained in a truncated hypodermic syringe. After the required period of time, the column is extruded from the syringe, cut into slices, and each slice analysed. The reproducibility of the method was established by following the migration of 4-hydroxybenzoic acid from isopropyl myristate solution into glycerol suppository base, and the technique extended to soft and hard gelatin capsule bases. The influence of temperature indicated that Arrhenius type plots could be used for accelerated testing, and migration from 1-octanol, isopropyl myristate and blends of the two showed that the rate and extent of migration were dependent upon the partition coefficient.
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