Abstract
A system for incorporating antimicrobial zinc into polymeric materials, in particular hydrogel type polymers has been developed. Zn(Bipy-(MMOES)2) a zinc carboxylate monomer was designed with the purpose of mimicking commercial cross linking agents such as ethylene glycol diacrylate, as well as containing antimicrobial zinc ions (Zn2+), with the intention that it can be used to cross link into any polymeric material, the example here being polyacrylic acid. Two systems were studied: a homopolymer of the Zn(Bipy-(MMOES)2) and copolymers of Zn(Bipy-(MMOES)2) with acrylic acid (AA). The AA – Zn(Bipy-(MMOES)2) produced water swellable polymers which retained antimicrobial activity. The ability of the polymers to release the zinc ions was shown to be pH responsive and the leachate analysed to give a proposed mechanism of action. The Zn(Bipy-(MMOES)2) monomer and polymers have shown antibacterial activity against both gram positive Methicillin susceptible staphylococcus aureus (MSSA 476) and gram negative Pseudomonas aeruginosa (PA01).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
