Abstract
Summary The existence of a common antigen of mouse cells and virulent Salmonella typhimurium, as postulated by Rowley and Jenkin, has been confirmed. It has been shown to be the C-antigen, shared by mouse tissue cells and erthrocytes. The The antigen was detected by mixed agglutination between these cells using rabbit anti-erythrocyte sera or pig normal sera. This reaction was abollished by prior absorption of the sera with S. typhimurium, without concurrent reduction of the direct mouse hemagglutination titer of the sera. Rowley and Jenkin hypothesized that mice were susceptible to S. typhimurium infection because they recognized the common antigen as a “self” component and, so, failed to make an immune response against the bacterium. However, the C-antigen has been found in two strains of mice which differ by 1000-fold in their susceptibility to S. typhimurium and also in rats which are highly resistant to the bacterium.
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