Abstract
Although the treatment of burn wounds has made great progress, the incidence of wound infection is still the main cause of high mortality. In this study, a silk fibroin (SF) scaffold wound dressing incorporated with Gentamicin Sulfate (GS) was developed for the treatment of burn infected wounds, in which GS was used as anti-bacterial agent. GS was mixed with silk fibroin solution and then processed into GS-SF composite scaffold via electro-spinning. The results showed the scaffold exhibited uniform polyporous morphology with 80% porosity. Induced by methanol, the scaffold presented much improved mechanical properties and stability to protease XIV. More important, the scaffold presented significant growth inhibition on both Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria.
Highlights
Skin is the largest organ of human body, which is composed of epidermis, dermis and subcutaneous adipose tissue
A silk fibroin (SF) scaffold wound dressing incorporated with Gentamicin Sulfate (GS) was developed for the treatment of burn infected wounds, in which GS was used as anti-bacterial agent
The results showed that GS-SF wound dressing scaffold with sufficient porosity presented excellent mechanical properties and stability, with significant growth inhibition on both Gram-positive and Gram-negative bacteria, which indicated that GS-SF composite scaffold might provide a useful strategy for development of new wound dressing for burn wounds
Summary
Skin is the largest organ of human body, which is composed of epidermis, dermis and subcutaneous adipose tissue. A complete skin surface is very important for the human body, which can maintain fluid balance and regulate the body temperature to protect the body from infection [1]. It prevents the wound from healing and may even lead to death, so throughout the history of human health, burn infection has always been a constant threat [2] [3]. It becomes more and more necessary to develop wound dressing scaffolds to reduce the incidence rate of burn infection and promote the wound healing of full-thickness defect
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