Abstract
To prevent infections associated with medical implants, various antimicrobial silver-coated implant materials have been developed. However, these materials do not always provide consistent antibacterial effects in vivo despite having dramatic antibacterial effects in vitro, probably because the antibacterial effects involve silver-ion-mediated reactive oxygen species generation. Additionally, the silver application process often requires extremely high temperatures, which damage non-metal implant materials. We recently developed a bacteria-resistant coating consisting of hydroxyapatite film on which ionic silver is immobilized via inositol hexaphosphate chelation, using a series of immersion and drying steps performed at low heat. Here we applied this coating to a polymer, polyetheretherketone (PEEK), and analyzed the properties and antibacterial activity of the coated polymer in vitro and in vivo. The ionic silver coating demonstrated significant bactericidal activity and prevented bacterial biofilm formation in vitro. Bio-imaging of a soft tissue infection mouse model in which a silver-coated PEEK plate was implanted revealed a dramatic absence of bacterial signals 10 days after inoculation. These animals also showed a strong reduction in histological features of infection, compared to the control animals. This innovative coating can be applied to complex structures for clinical use, and could prevent infections associated with a variety of plastic implants.
Highlights
To prevent infections associated with medical implants, various antimicrobial silver-coated implant materials have been developed
We recently developed a bacteria-resistant coating consisting of hydroxyapatite film, on which ionic silver is immobilized via inositol hexaphosphate chelation using a low-heat immersion p rocess[14]
The presence of Pt was due to sputtering prior to the scanning electron microscopy (SEM) observation. These results indicated that HAp aggregates were precipitated onto the PEEK substrate, and that A g+ ions were immobilized on the HAp film by the chelate-bonding ability of inositol phosphate 6 (IP6)
Summary
To prevent infections associated with medical implants, various antimicrobial silver-coated implant materials have been developed. We recently developed a bacteria-resistant coating consisting of hydroxyapatite film on which ionic silver is immobilized via inositol hexaphosphate chelation, using a series of immersion and drying steps performed at low heat. We applied this coating to a polymer, polyetheretherketone (PEEK), and analyzed the properties and antibacterial activity of the coated polymer in vitro and in vivo. We recently developed a bacteria-resistant coating consisting of hydroxyapatite film, on which ionic silver is immobilized via inositol hexaphosphate chelation using a low-heat immersion p rocess[14] This coating onto the metal demonstrates remarkable antibacterial activity both in vitro and in vivo[14]. It is generally difficult to process any coatings on PEEK because of its chemical stability, and there had been no previous report on its antibacterial processing
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