An anthropomorphic deformable phantom for brain shift simulation

Abstract

The prominent soft tissue deformation during a neurosurgical procedure, the so called brain shift phenomenon, affects the accuracy of the surgery greatly. Although the feasibility of numerous intraoperative modalities is investigated for the brain shift compensation, another state-of-the-art interventional imaging modality C-Arm CT is rarely studied in this context. Due to the lack of clinical data, a suitable anthropomorphic deformable phantom is indispensable. The purpose of this study is to describe and determine the characteristics of a multi-modal deformable brain phantom made out of polyurethane and ceramic composite bone material. The phantom is made of six parts: skin, skull, brain, blood vessels, ventricles and an inflatable tumor. Fluid can be filled into the blood vessels, the ventricles and the tumor in order to simulate the brain shift phenomenon. Such an anthropomorphic phantom is both visible with MR and C-Arm CT scanner. In order to evaluate the clinical relevance of our phantom, we induce deformations with different degrees by in- and deflated the embedded tumor in 5 steps. Both MR and C-Arm CT (cone beam CT) images are acquired in each step. The induced deformation is estimated by performing mono-modal deformable registration with symmetric normalization method (SyN) both on MR and cone beam CT (CBCT) acquisitions. The maximum displacement estimated with MR and CBCT pair is 29.6mm and 28.1mm. This result correlates the clinical findings.