Abstract
Sitagliptin is an oral anti-hyperglycemic agent of the dipeptidyl peptidase-4 (DPP-4) inhibitor magnificence used inside the remedy of type-2 diabetes. It stimulates insulin release and reduces glucagon levels by inhibiting of inactivation of the incretin in a glucose-dependent manner. In 2013 it was the second best- selling drug in the U.S. This evaluation encompasses diverse analytical strategies inclusive of spectrometry, high-overall performance liquid chromatography (HPLC), liquid chromatography-electrospray ionization- mass spectrometry (LC-ESI-MS-MS), liquid chromatography-mass spectrometry (LC-MS), capillary electrophoresis (CE), ultra-overall performance liquid chromatography (UPLC), high-overall performance skinny layer chromatography (HPTLC) and fuel line chromatography-mass spectrometry (GC-MS) for the estimation of sitagliptin in unmarried and/or in combination. Keywords: Sitagliptin, Analytical methods, Type-2 diabetes.
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