An analysis on the results of thinprep liquid based cytological test in 10 000 patients

Abstract

Objective By analying 10 000 thinprep liquid based cytological test (TCT) results,we assessed the value of TCT in the diagnosis of cervical disease; and then we explored the rate of concordance between positive cervical cytological interpretation based on liquid-based preparations and subsequent histological diagnosis.Methods The diagnosis of 10 000 patients was made according to the criteria of Bethesda system (TBS),and then compared with the TCT results and the histological diagnosis in the patients with positive results.Results Of the 10 000 patients,561 (5.61％) were abnormal including 18 ASC-H,333 ASCUS,164 LSIL,44 HSIL,one cancer,and one AGC-N.The high-risk of cervical cytology focused on twenty to fifty years,with ASCUS and LSIL mainly in the twenty-years old,ASC-H and HSIL mainly concentrated in the thirty to fifty years old.By comparing with histological diagnosis,LSIL coincidence rate was 71.6％ and HSIL was 77.8％.Conclusions Cervical epithelial lesions have a trend in younger people.TCT has a high agreement with biopsy in positive rate,which suggests that TCT has certain predicative value for pathological results. Key words: Thinprep liquid based cytological test; Histological diagnosis; Coincidence rate