An analysis on prognostic factors of hilar cholangiocarcinoma

Abstract

To investigate the influencing factors on the prognosis of hilar cholangiocarcinoma. The clinical data were retrospectively analyzed in 86 cases of hilar cholangiocarcinoma admitted into our hospital from Jan. 2004 to July. 2008. Of 86 cases with hilar cholangiocarcinoma, the mean survival time was 13.7 +/- 2.3 months, 1-year survival 57.3% and 3-year survival 29.7%. The mean survival time in patients with resection operation (19.4 +/- 2.2 months) was significantly longer than those with no operation (7.2 +/- 1.2 months) (P < 0.05). The mean survival time in patients with non-vascular resection group (23.4 +/- 2.1 months) was significantly longer than those with portal vein resection alone group (15.3 +/- 1.4 months) and hepatic artery resection group (9.3 +/- 0.9 month) (P < 0.05). Cox regression analysis showed that staging, tumor diameter and operative were the dependent prognosis factors while pathologic type, vascular resection and age not the dependent prognosis factors. The prognosis of hilar cholangiocarcinoma correlates with operative approach, clinical stage and tumor diameter. A surgeon must be cautious to choose the surgical approach for treatment.