Abstract
Eight secondary metabolites including three new sesquiterpenoids, named dendronobin (1), dendrobilin L (2) and 1,4-trans-12-hydroxycalamenene-12-O-β-D-glucoside (3), together with five known compounds, dendrobine (4), nobiline (5), dihydroxyconiferyl alcohol (6), 5-methoxy-(+)-isolariciresinol (7), lyoniresinol (8) were isolated from the stems of Dendrobium nobile Lindl. Their structures were determined by extensive spectral analysis using HR-ESI-MS and NMR spectra (1H, 13C, 1H-1H COSY, HSQC, HMBC, and NOESY), and the absolute configurations of compounds 1-3 were determined by electronic circular dichroism (ECD) and theoretical calculations. Among these metabolites (1-8), dendronobin L (2) possessed a unique carbon skeleton. A potential biosynthetic pathway from dendronobin L (2) to dendrobine was suggested. Nobiline (5), dihydroxyconiferyl alcohol (6) and 5-methoxy-(+)-isolariciresinol (7) showed weak antioxidant activity.
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