Abstract
Tonic vasoconstriction of rabbit ear artery depends mainly upon influx of extracellular Ca++ through plasmalemmal calcium channels activated by depolarization (voltage-operated channel) or by stimulation of specific receptors (receptor operated channel) (4,5,16,17,19). Taurine has been shown to be an effective antagonist of depolarization- but not norepinephrine-induced tonic vasoconstrictions in rabbit ear artery (8,9), suggesting a selective interference on the availability of the voltage operated channel. However, in vascular smooth muscle other sources of calcium are involved in excitation-contraction coupling; for example release of calcium from internal store such as sarcoplasmic reticulum (4).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
