An Analysis of Severe Acure Respiratory Syndrome Coronavirus-2 (Sasrs-COV-2) Antibody Levels Determinant of Society in Gowa Regency

Abstract

Covid-19 is a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Specific antibody detection can provide information about adaptive immunity against SARS-CoV-2. This study aims to identify and analyze the determinants of SARS-CoV-2 antibody levels based on data from the results of the SARS-CoV-2 Seroprevalence Survey in Indonesia. This study was an analytic observational study with a cross sectional study design. The Total of samples was 851 samples. The sampling technique used purposive sampling with the SARS-CoV-2 Seroprevalence Survey. Data analysis used STATA version 14.0 with chi-square test and multiple logistic regression. There was a difference among the SARS-CoV-2 antibody levels Determinant based on the type of vaccine (p=0.001), vaccine dose (p<0.001) and time interval of last vaccination (p=0.002). The results of the multivariate analysis showed that vaccine dose was the most related variable to SARS-CoV-2 antibody levels (p = 0.004) after removing the variable type of vaccine and time interval of last vaccination. The most related variable is the vaccine dose with the possible type of vaccine and time interval of last vaccination as confounding factor. Vaccination scope for Covid-19 dose 2 and 3 should be further improved and given according to the administration schedule that related to type of vaccine as well as choosing RNA-based vaccine type which given to people in Gowa Regency.