An Analysis of Plasma Thiol/Disulphide Homeostasis in Patients with Stable Angina

Abstract

Objective: To investigate thiol/disulfide homeostasis in patients with stable angina pectoris.Materials and Methods: The study population consisted of 85 stable angina pectoris patients and 31 healthy volunteers. To compare the thiol/disulfide values of the patients and controls, the newly developed analysis method was used by Erel and Neselioglu. Disulfide/total thiol, free thiol/total thiol and disulfide/free thiol values were calculated for both groups.Results: Disulfide, free thiol and total thiol values obtained in the study were; 18.00 µmol/L, 365.08 µmol/L, 401.10 µmol/L for the patient group and 9.67 µmol/L for the control group, 372.51 µmol/L, 391.85 µmol/L for the control group. It is the first time thiol/disulphide homeostasis in plasma was examined by new developed method in stable angina pectoris patients with this study. Disulfide, disulfide/free thiol and disulfide/total thiol values were significantly higher in the patient group compared to the control group. free thiol/total thiol levels were significantly lower in patients (p<0.001).Conclusion: Thiol and disulfide values can be seen at high levels in patients with stable angina pectoris, so thiol/disulfide homeostasis may be an indicator for this disease.