An Analysis of Computed Tomography Imaging Features and Predictive Factors for Postoperative Recurrence and Metastasis of Abdominal Paragangliomas.

Bailing Dai,Zongyu Xie,Xiaoli Zhou,Xiandi Zhu,Jian Wang,Cui Zhang,Jie He,Zhao Yang,Yuvaraja Teekaraman

doi:10.1155/2022/8638588

Abstract

Methods We studied 51 abdominal PGL patients at the First Affiliated Hospital of Bengbu Medical College, Tongde Hospital, and Sir Run Shaw Hospital, Hangzhou, Zhejiang Province, China, from June 2009 to May 2019. Thereafter, the clinical research data, tumor biomarkers, and CT features were compared between the aggressive PGLs and the nonaggressive PGLs using independent-samples t-tests and chi-square tests. Results Of the 51 cases, 43 were benign and 8 had malignant tendencies. Postoperative recurrence and metastasis were more likely to occur when the tumor diameter was >8 cm or/and the enhancement degree was not obvious. Clinical symptoms, tumor markers, sex, age, and CT image characteristics including morphology, presence of cystic degeneration, “pointed peach” sign, calcification, hemorrhage, enlarged lymph nodes, and peritumor and intratumor blood vessels were not significantly different between the two groups (p > 0.05). Conclusion Our findings suggest that CT features, including size >8 cm and enhancement degree, could provide important evidence to assess risk factors for aggressive PGLs.

Highlights

Pheochromocytomas (PCC) and extra-adrenal paragangliomas (PGLs) are identical diseases that are named differently depending on their anatomical location. e World Health Organization decided to assign the term “pheochromocytoma” to refer exclusively to tumors occurring in the adrenal medulla and “extra-adrenal PGLs” as tumors occurring in other tissues [1]
A total of 51 patients were enrolled in this study with 8 PGL patients with metastasis or recurrence composed the aggressive group, while the nonaggressive group was composed of 43 PGL patients without recurrence or metastasis. is retrospective observational study was obtained for institutional review board approval, and all participants provided written informed consent
E details of the demographic and clinical characteristics have been summarized in Table 1. ere were 30 female and 21 male participants; the mean ± SD age was 52.8 ± 14.5 years

Summary

Introduction

Pheochromocytomas (PCC) and extra-adrenal paragangliomas (PGLs) are identical diseases that are named differently depending on their anatomical location. e World Health Organization decided to assign the term “pheochromocytoma” to refer exclusively to tumors occurring in the adrenal medulla and “extra-adrenal PGLs” as tumors occurring in other tissues [1]. Accurate prediction of the prognostic risk factors of PGLs preoperatively and developing a well-grounded therapy guide are determinative to increasing the survival rate. Several biomarkers, including cortisol, CEA, CA199, CA125, and renin, are used to be comprehensive tumor diagnosis. Recurrence and metastasis are the most important factors influencing the survival rate of patients with paragangliomas (PGLs). Accurate preoperative prediction of the risk factors and developing a reasonable therapy strategy can reduce the recurrence rate. Tumor markers, sex, age, and CT image characteristics including morphology, presence of cystic degeneration, “pointed peach” sign, calcification, hemorrhage, enlarged lymph nodes, and peritumor and intratumor blood vessels were not significantly different between the two groups (p > 0.05). Our findings suggest that CT features, including size >8 cm and enhancement degree, could provide important evidence to assess risk factors for aggressive PGLs

Methods

Results

Discussion

Conclusion