An analysis of biochemical markers of bone metabolism in patients with idiopathic benign paroxysmal positional vertigo

Abstract

Objective:To analyze the biochemical markers of bone metabolism in patients with idiopathic benign paroxysmal positional vertigo（iBPPV）. Method:The study included 38 patients with iBPPV. Thirty-two healthy persons were collected as control group. Routine history collection, physical examination, and diagnosis were recorded in case group. Both the case group and control group were assessed for the status of bone biochemical markers. Result:①Among the 38 patients with iBPPV, posterior semicircular canal BPPV in right ear（R-PC-BPPV）presented in 23 cases , left ear（L-PC-BPPV）in 9 cases, horizontal semicircular canal BPPV in right ear in 2 cases, and in left ear in 2 cases, horizontal semicircular canal cupulolithiasis in 2 cases. ②The value of osteocalcin(OC), 25 hydroxyvitamin D3［25(OH)D3］, amino terminal propeptide of type I procollagen (PINP) in case group were lower than the normal reference value, and also significantly lower than that in the control group,OC: t=-2.013, P=0.048; 25(OH)D3: t=-2.133，P=0.037; PINP: t=-2.615,P=0.011. There was no significant difference of β-isomerized carboxy-terminal telopeptide of type I collagen (β-CTx) between the case group and control group. ③The value of OC(t=-2.187，P=0.035), 25(OH)D3(t=-2.190，P=0.035) and PINP(t=-2.322，P=0.026) in patients lower than 50 years old were significantly lower than that in the control group. The difference of these biochemical markers between the case and control group was not significant when subjects were ≥50 years old. Conclusion:The biochemical markers of bone metabolism in patients with iBPPV are declined, especially in patients lower than 50 years old. There may be abnormal bone metabolism in iBPPV patients.