An analysis of bacterial pathogens in low respiratory tract infection in neonate with mechanical ventilation

Abstract

Objective To investigate the characteristics of low respiratory Watt pathogenic bacteria and their antimicrobial resistance in neonate with mechanical ventilation in intensive care unit.Methods An retrospective clinical data of analysis of low respiratory tract secretion culture and drug-sensitivity test was done to 107 newborns with mechanical ventilation ＞48 hours.Results The incidence rate of low respiratory tract infection in neonates with mechanical ventilation was 76.6%(82/107).The rate of Gram-positive bacteria was 13.4%(11/82),that of Gram-negative bacteria was 81.7%(67/82)and that of the fungi was 4.9%(4/82).The most common Gram-negative bacteria was Klebsiella pneumonia which was 59.7%(40/ 67)and with 82.5 % being ESBLs-producing strains(33/40).The resistance of ESBLs-producing Klebsiella pneumonia was higher to cephalosporins and the resistance to antibiotics supplemented with β-lactamaseinhibitors were significantly lower,but sensitive to tienam,ciprofloxacin and amikacin.Conclusion The main pathogens of low respiratory tract infection are Gram-negative bacteria and drug-resistant opportunistic bacteria in neonate with mechanical ventilation.ESBLs-producing Klebsiella pneumonia is the major pathogen. Key words: Mechanical ventilation; Low respiratory tract infection; Etiology; Neonate