Abstract
Introduction Previously, we described the significant linkage of bipolar affective disorder (BPAD) with a 14 cM region of chromosome 4p15-16 in a single large Scottish pedigree (F22). A number of independent groups have subsequently provided additional evidence for linkage to this region. It is likely that a founder mutation is responsible for these linkage signals and would be co-inherited with a region of flanking sequence.
Highlights
We described the significant linkage of bipolar affective disorder (BPAD) with a 14 cM region of chromosome 4p15-16 in a single large Scottish pedigree (F22)
We describe a strategy for identifying regions of excess allele sharing between hypothesised mutation carrying chromosomes when compared to control chromosomes of the linked families
Following up multiple linkage analysis results with allele & haplotype sharing analysis has allowed us to progress from a large linkage region to small regions of allele sharing
Summary
Address: Medical Genetics Section, School of Molecular and Clinical Medicine, The University of Edinburgh, UK. phlettmpe:/n/wt>wmcBeniotSrayls.Bcoiom: /Bcioonintefonrtm/padtfi/c1s4a7n1d-2S1y0s5te-6m-Ss3B-ionflo.gpydCfre Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
