An amplified electrochemical sensor employing one-step synthesized nickel-copper-zinc ferrite/carboxymethyl cellulose/graphene oxide nanosheets composite for sensitive analysis of omeprazole.

Abstract

In this work, a signal amplification strategy was designed by the fabrication of a highly sensitive and selective electrochemical sensor based on nickel-copper-zinc ferrite (Ni0.4Cu0.2Zn0.4Fe2O4)/carboxymethyl cellulose (CMC)/graphene oxide nanosheets (GONs) composite modified glassy carbon electrode (GCE) for determination of omeprazole (OMP). The one-step synthesized Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs nanocomposite was characterized by scanning electron microscopy, energy-dispersive X-ray spectroscopy, transmission electron microscopy and X-ray diffraction techniques. Then, the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE was applied to study the electrochemical behavior of the OMP. Electrochemical data show that the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE exhibits superior electrocatalytic performance on the oxidation of OMP compared with bare GCE, GONs/GCE, CMC/GONs/GCE and MFe2O4/GCE (M = Cu, Ni and Zn including single, double and triple of metals) which can be attributed to the synergistic effects of the nanocomposite components, outstanding electrical properties of Ni0.4Cu0.2Zn0.4Fe2O4 and high conductivity of CMC/GONs as well as the further electron transport action of the nanocomposite. Under optimal conditions, the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE offers a high performance toward the electrodetermination of OMP with the wide linear-range responses (0.24-5 and 5-75 μM), lower detection limit (0.22 ± 0.05 μM), high sensitivity (1.1543 μA μM-1 cm-2), long-term signal stability and reproducibility (RSD = 2.54%). It should be noted that the Ni0.4Cu0.2Zn0.4Fe2O4/CMC/GONs/GCE sensor could also be used for determination of OMP in drug and biological samples, indicating its feasibility for real analysis.