An Amidochlorin-Based Colorimetric Fluorescent Probe for Selective Cu(2+) Detection.

Wenting Li,Jinghua Li,Yingxue Jin,Guohua Zhu,Zhiqiang Wang

doi:10.3390/molecules21010107

Abstract

The design and synthesis of selective and sensitive chemosensors for the quantification of environmentally and biologically important ionic species has attracted widespread attention. Amidochlorin p6 (ACP); an effective colorimetric and fluorescent probe for copper ions (Cu2+) in aqueous solution derived from methyl pheophorbide-a (MPa) was designed and synthesized. A remarkable color change from pale yellow to blue was easily observed by the naked eye upon addition of Cu2+; and a fluorescence quenching was also determined. The research of fluorescent quenching of ACP-Cu2+ complexation showed the detection limit was 7.5 × 10−8 mol/L; which suggested that ACP can act as a high sensitive probe for Cu2+ and can be used to quantitatively detect low levels of Cu2+ in aqueous solution. In aqueous solution the probe exhibits excellent selectivity and sensitivity toward Cu2+ ions over other metal ions (M = Zn2+; Ni2+; Ba2+; Ag+; Co2+; Na+; K+; Mg2+; Cd2+; Pb2+; Mn2+; Fe3+; and Ca2+). The obvious change from pale yellow to blue upon the addition of Cu2+ could make it a suitable “naked eye” indicator for Cu2+.

Highlights

IntroductionThe design and synthesis of selective and sensitive chemosensors for the quantification of environmentally and biologically important ionic species has attracted widespread attention [1]
The design and synthesis of selective and sensitive chemosensors for the quantification of environmentally and biologically important ionic species has attracted widespread attention [1].Among ionic species, copper is one of the important pollution sources [2]
As a common heavy metal existing widely in Nature and all living organisms, an appropriate amount of copper ion is essential to living organisms because it is a key constituent of the respiratory enzyme complex cytochrome c oxidase [3]

Summary

Introduction

The design and synthesis of selective and sensitive chemosensors for the quantification of environmentally and biologically important ionic species has attracted widespread attention [1]. Copper is one of the important pollution sources [2]. The determination of heavy metal content in living organisms and the environment is important. Because chromo- or fluoroionophores are highly effective for these determinations, given their easy handling and the simple equipment required, effort has been expended to develop optical chemosensors that selectively respond to the Cu2+ ion. As Molecules 2016, 21, 107; doi:10.3390/molecules21010107 www.mdpi.com/journal/molecules paramagnetic

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