An Ambient Protocol for Polycyclic 1,4-Dihydropyridines Using a Heterogeneous Catalyst

Abstract

Heterogeneous catalysts are chemical catalysts whose physical phase is different from the physical phase of the reactants and products of the chemical reaction being catalyzed. In recent years much interest has been shown in the efficient use of heterogeneous catalysts for the synthesis of biologically relevant heterocycles. In the present investigation, a scaffold of polycyclic 1,4-Dihydropyridines has been synthesized in ambient conditions utilizing the catalytic properties of cupric sulfate pentahydrate. The catalyst was found to be indispensable for carrying out the reaction in ambient conditions. The protocol described herein is benign, convenient, versatile, highly efficient, and free of harmful chemicals. The synthesized compounds were characterized by IR, 1H NMR, LC-Mass spectroscopic techniques, and elemental analysis.