Abstract
The NaChBac voltage-gated sodium channel from Bacillus halodurans is a homo-tetramer, which matches the quaternary structure of potassium channels but contrasts with the single-chain mammalian sodium channels. We have previously demonstrated that the cytoplasmic C-terminus of NaChBac functions as a channel assembly domain [Powl et al (2010) PNAS 107:14064-14069]. Sequential deletion mutations reduce the amount of NaChBac in the membrane fraction, with removal of the entire C-terminus eliminating the channel assembly.
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