An alternative process for one-pot multicomponent synthesis of substituted 2, 4, 5-triphenylimidazoles using activated Fuller's earth as catalyst and molecular modeling data

Abstract

We have successfully achieved the synthesis of 2,4,5-trisubstituted imidazole by a three pot multicomponent reaction of benzil, aromatic benzaldehydes and ammonium acetate in presence of activated fuller's earth as a catalyst. The activation of fuller's earth is carried out by an organic acid, which sufficiently increased its adsorption properties. The advantages of this process are high yields, green system and efficient recovery of the catalyst, which can be reused 2–3 times without much significant effect on yield. Molecular Modelling studies viz., Lipinski rule of five, drug likeness, drug scores, toxicity profiles and other physico-chemical properties of drugs were performed using Molinspiration and Osiris software and compared with the data of standard drug molecule.