Abstract
We propose in this work a novel optimization strategy for intensity-based non-rigid image registration of contrast-enhanced images with a volume-preservation constraint. The optimization method alternates between under-constrained registration (allowing the elimination of motion artifacts in the subtraction images) and over-constrained registration (enforcing volume preservation of contrast-enhanced structures). We apply our method to pre- and post-contrast MR breast images from 17 patients and demonstrate its capability to simultaneously achieve volume preservation and artifact reduction.
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