Year-end Sale % OFF 
Abstract
Sleep deprivation (SD) leads to impairments in cognitive function. Here, we tested the hypothesis that cognitive changes in the sleep-deprived brain can be explained by information processing within and between large-scale cortical networks. We acquired functional magnetic resonance imaging (fMRI) scans of 20 healthy volunteers during attention and executive tasks following a regular night of sleep, a night of SD, and a recovery nap containing nonrapid eye movement (NREM) sleep. Overall, SD was associated with increased cortex-wide functional integration, driven by a rise of integration within cortical networks. The ratio of within versus between network integration in the cortex increased further in the recovery nap, suggesting that prolonged wakefulness drives the cortex towards a state resembling sleep. This balance of integration and segregation in the sleep-deprived state was tightly associated with deficits in cognitive performance. This was a distinct and better marker of cognitive impairment than conventional indicators of homeostatic sleep pressure, as well as the pronounced thalamocortical connectivity changes that occurs towards falling asleep. Importantly, restoration of the balance between segregation and integration of cortical activity was also related to performance recovery after the nap, demonstrating a bidirectional effect. These results demonstrate that intra- and interindividual differences in cortical network integration and segregation during task performance may play a critical role in vulnerability to cognitive impairment in the sleep-deprived state.
Highlights
IntroductionThe cognitive consequences of acute total sleep deprivation (SD) are substantial, negatively affecting a wide range of processes including attention, vigilance, and working memory [1,2]
The cognitive consequences of acute total sleep deprivation (SD) are substantial, negatively affecting a wide range of processes including attention, vigilance, and working memory [1,2].developed by the authors for the execution of the study, and is available online at https://github.com/ nathanecross/sleep-deprivation
Previous comparisons of nonrapid eye movement (NREM) sleep were with the wakeful resting state, the current findings demonstrate that these effects generalise to other states of wakefulness
Summary
The cognitive consequences of acute total sleep deprivation (SD) are substantial, negatively affecting a wide range of processes including attention, vigilance, and working memory [1,2]. Developed by the authors for the execution of the study, and is available online at https://github.com/ nathanecross/sleep-deprivation. Raw data are restricted due to legal/ethical considerations. They may be shared with other investigators upon reasonable request and network modularity [6]. Very few studies have investigated the changes in brain con-
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
