Abstract
Blood viscosity is one of the important parameters to characterize hemorheological properties of the human body. Its real-time and dynamic measurement has important physiological significance for studying the development and prevention of chronic diseases. This study researched noninvasive and personalized measurement of microvascular blood viscosity. In the microcirculation capillary network blood flow model, combined with pulse wave parameters, multiple regression analysis was used to fit the simulated radius of personalized physiological blood vessels to calculate the microvascular blood viscosity. The fitted value related to the simulated radius of the physiological blood vessel had a high correlation with the corresponding theoretically derived value (correlation coefficient: 0.904, P ≤ 0.001). The calculated value of the microvascular blood viscosity had a certain correlation with the clinical whole blood viscosity at a low shear rate (correlation coefficient: 0.443, P < 0.05). This algorithm could provide effective means for noninvasive and long-term individual monitoring and family health care.
Highlights
Hypertension, hyperglycemia, and hyperlipidemia have become high-risk factors for cardiovascular diseases such as coronary heart disease, atherosclerosis, and myocardial infarction [1,2,3,4,5,6]
Blood viscosity is the internal friction generated between the various molecules inside the blood when it flows in the blood vessels
PP, BSA, and CO could be calculated from clinical data
Summary
Hypertension, hyperglycemia, and hyperlipidemia have become high-risk factors for cardiovascular diseases such as coronary heart disease, atherosclerosis, and myocardial infarction [1,2,3,4,5,6]. Hyperlipidemia and other diseases normally have a blood viscosity abnormality syndrome before the obvious symptoms appeared [7,8,9]. Blood viscosity can be evaluated based on whether an individual is in an abnormal state of blood viscosity, thereby providing auxiliary means for monitoring of hyperlipidemia. Blood viscosity is the internal friction generated between the various molecules inside the blood when it flows in the blood vessels. It characterizes the condition of blood circulation or supply [10, 11]. The change law of blood viscosity can provide useful data for the diagnosis, treatment, and prognosis of the disease [12,13,14]
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