An Algorithm for operating a fed‐batch fermentation using quasi‐steady state

Abstract

AbstractThe determination of an optimum feeding profile of a fed‐batch fermentation requires the solution of a singular optimum control problem, which is often complicated by changes in the process kinetics during the fermentation. The procedure of optimization may be sufficiently simple, if the feeding part of fermentation is carried out in the quasi‐steady state. In this work an algorithm for operating a fed‐batch fermentation using mentioned regime is offered. The algorithm supposes a periodical correction of the feeding strategy. Applying to fed‐batch lysine fermentation demonstrate efficacy of this algorithm over frequently used strategies.