Abstract
Objective To investigate the neural substrate of empathy processing by ALE meta-analysis. Methods Literatures in Pubmed, Web of science, Medline, Sciencedirect, CNKI were reviewed with requirements: ①Exploring the neural mechanisms of empathy by fMRI techniques, and healthy adult subjects were included; ②Using the Talairach or MNI coordinate to report the activated brain regions, and the complete data could be attached. Calculated ALE value of included 68 articles through the ginger ALE 2.3, and attained the brain map. Results The empathy processing activated the insula, cingulate, inferior frontal gyrus, inferior parietal lobule and so on. Conclusion Insula and cingulate play a vital role in the empathy, besides, the human mirror neuron system is closely associated with the empathy. Key words: Empathy; fMRI; ALE meta-analysis
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