Abstract

ObjectivesThe number of reported cases of multiresistant Mycoplasma genitalium (MG) is increasing globally. The aim of this study was to estimate the prevalence of macrolide and possible fluoroquinolone resistance-associated mutations...

Highlights

  • Mycoplasma genitalium (Mg) is an emerging sexually transmitted infection (STI) and its global burden of disease is not very well known so far.[1]

  • Prevalence varies among different risk populations – and is generally higher in men who have sex with men (MSM) and female sex workers compared to other heterosexual individuals

  • Around one quarter of the patients had more than one positive Mg result over the four years (22.6%; n=48/212), most of them (79.1%; n=38/48) were part of the Be-pre-exposure prophylaxis (PrEP)-ared study

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Summary

Introduction

Mycoplasma genitalium (Mg) is an emerging sexually transmitted infection (STI) and its global burden of disease is not very well known so far.[1]. A systematic review and meta-analysis up to 2017 found the prevalence of Mg to be 0.9% in pregnant women, 3.2% in MSM and 15.9% in female sex workers.[2] The prevalence of Mg in MSM, is, reaching 10% according to the most recent publications.[3,4,5,6] Mg is a cause of non-gonococcal urethritis in men and cervicitis in women, but Mg is frequently found in asymptomatic individuals.[5] The natural history and clinical consequences of asymptomatic Mg infections are still poorly understood and including Mg in screening programmes among high risk groups is, not recommended. Mg positive samples should be further analysed for the presence of macrolide resistance RAMs to tailor patient treatment and management.[7]

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