An advance of complex multifaceted root learning for parkinson behavior using subthalamic nucleus biomarkers

Abstract

Though DBS is suiting well to Parkinson`s still its current version being modified now and often as suggested by the neuroscientists. The technique has gained an effectual management surgical therapy concerned to PD, explicitly whilst growing idea as an effectual method to alleviate Parkinson’s disease and other movement disorders. The present ver.1 indirect DBS is an open loop based and its parameters are changeable manually and there is no provision to adjust automatically or online based on Parkinson diseased behavior and performance. Hence, supervised classification of patient behavior is a major and significant step towards the design of next generation DBS systems which are adaptive closed loop based. The work in this study demonstrates a supervised classification machine learning (CML, i.e., multiple kernel learning M-K-L) method to distinguish such cognitive behavioral tasks by using the subthalamic nuclei (STN) biomarkers, i.e., biomedical data of microelectrode recording (MER) bio signals (or local field potential LFP). We applied the time domain and frequency domain representation spectrograms of the raw data acquired from right and left hemisphere brain`s STNs as the feature vectors. Following the feature extractions, we combined those features via support vector machines (SVMs) with complex multifaceted root learning, i.e., C-M-L or multi kernel learning (M-K-L) formulation. The C-M-L based classification techniques were applied to a class and categorize different tasks such as switch (push-pull button), movement of jaws, vocalizations, plus movement of arm due to the tremor. Our experiments show that the l - n o r m C-M-L/M-K-L radically smash distinct kernel SVM-based classifiers in classifying behavioral tasks of five subjects even using signals acquired with a low sampling rate of 10 Hz. This leads to a lower computational cost.