An Adolescent Girl with Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome

Hana Setterquist Hana Setterquist,Kinsley Stepka Kinsley Stepka

doi:10.36013/jrdod.v2i.41

Abstract

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare and poorly understood condition that is likely underdiagnosed. The possibility that uveitis and acute tubulointerstitial nephritis do not occur simultaneously may make diagnosis more difficult. Treatment consists of systemic corticosteroids and potentially non-steroid immunosuppressants. Renal disease usually resolves spontaneously or with appropriate treatment, however, ocular manifestations may be chronic or relapsing. We report a case of tubulointerstitial nephritis and uveitis syndrome in a 12-year-old female.

Highlights

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare cause of acute tubulointerstitial nephritis preceded by, accompanied with, or followed by uveitis [1]
5% of the cases of tubulointerstitial nephritis [2] and fewer than 2% of the cases of uveitis can be attributed to TINU syndrome; it has been estimated that it may account for up to a third of acute-onset bilateral anterior uveitis in patients under 20 years of age [3]
Diagnosis of TINU syndrome is made based on the combination of acute tubulointerstitial nephritis and uveitis and after exclusion of other potential causes, most notably systemic disease and infection [9]

Summary

Introduction

Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare cause of acute tubulointerstitial nephritis preceded by, accompanied with, or followed by uveitis [1]. 5% of the cases of tubulointerstitial nephritis [2] and fewer than 2% of the cases of uveitis can be attributed to TINU syndrome; it has been estimated that it may account for up to a third of acute-onset bilateral anterior uveitis in patients under 20 years of age [3]. Considering the laboratory results and clinical features, an initial diagnosis of acute on chronic renal failure due to tubulointerstitial nephritis was made.

Results

Conclusion