Abstract
This paper describes an adjustable method for body composition analysis of awake mice based on time domain nuclear magnetic resonance (TD-NMR) technology. A T1-weighted CPMG pulse sequence was introduced to acquire the NMR signals that contain both longitudinal (T1) and transversal (T2) relaxation information of mice. It took less than 90 s to dramatically lighten the burden on animals. A model training according to a well-designed factorial experiment was conducted by measuring a series of artificial samples, and the relations between NMR signals and body components (lean, fat and free fluid) were established. This NMR model gave a good fitting (R2 > 0.99) between real values and predictive values and measuring stability were also demonstrated. A calibration method was highlighted to figure out how to keep NMR model effective on another NMR scanner or avoid the error from fluctuation of machine without a time-consuming re-modeling process.
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