Abstract
The effects of variations in rate of microsphere injection and site and rate of reference sample withdrawal were studied to further define sources of error in microsphere measurements of regional blood flow. Anesthetized canines underwent sequential left ventricular injection of radiolabeled 25-μm microspheres at slow and fast injection speeds. Simultaneous reference samples were collected from brachial and femoral artieres at slow (5 ml/min) and fast (13 ml/min) withdrawal rates. Calculated renal blood flows (RBF) were compared for each injection rate, sampling site, and withdrawal rate. Varying injection rate or withdrawal site resulted in no significant differences in RBF. RBF was influenced significantly ( P < 0.005) by reference sample withdrawal (fast withdrawal 4.38 ± 1.28 ml/min·g vs slow withdrawal rate 6.87 ± 2.29 ml/min·g). Data indicate that selection of an inappropriately slow rate of reference sample withdrawal results in erroneous values of regional blood flow.
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