An Adaptive Control System for Regulation of the End-Expiratory Gas Concentration of Artificially Ventilated Animals

Abstract

This paper presents a practical discrete time adaptive control system for bio-medical applications. To regulate end-expiratory gas concentration of animals under artificial ventilation, a new control system was developed. Using automatic initialization and supervision functions, this method avoids the complicated selection of some design parameters in adaptive control and can keep safety operation during the experiment. In this methods, the regulation of the end-expiratory gas concentration is controlled by injectioning gases(CO2 and O2) into the inspiratory air of the animals. The volume of the gases are determined based on the estimated characteristics of the animals. In this paper, first, we design the adaptive control system, in the case where the characteristics of the animals are unknown. Next, we implement the control system and perform the animal experiments under several conditions. Extensive experimental results illustrate the feasibility of the proposed scheme.