An active electrolocation catheter system for imaging and analysis of coronary plaques

Abstract

Coronary artery disease—currently one of the most frequent causes of death—is characterized by atherosclerotic plaques grown in the wall of blood vessels and inhibiting blood flow. Preventive assessment focusses on critical sizes of structural plaque parameters like relative lipid core area and cap thickness to identify high-risk plaques called thin cap fibroatheromas. Although state-of-the-art catheter systems were successfully applied in invasive plaque diagnostics, the high costs induced by these devices inhibit usage in daily clinical practice. To overcome this shortcoming, we follow a biomimetic approach to construct a prospective low-cost catheter system that adapts the active electrolocation principles of weakly electric fish Gnathonemus petersii. Only a few and simple parameters relevant for plaque detection and characterization are estimated from plaque-evoked electric images which are projected on the surface of the catheter. Two prototypical electrolocation catheter systems were tested. The first catheter system featured a ring electrode catheter and was used to obtain dynamic 1D electric images of synthetic plaques in an agarose atherosclerosis model. Our proof of concept showed that synthetic plaques could be reliably detected from 1D electric images. Based on a cluster analysis of selected key image features, synthetic plaques could be categorized into four plaque conditions, predefined from thresholds for critical structural parameters, representing high to low risk plaques. In the second recording approach, plaque-evoked dynamic and static spatial electric images were obtained by a multi-electrode catheter system. Based on these recordings, a synthetic plaque with a critical cap thickness could be detected and localized in a pig coronary artery.