Abstract
A new acetohydroxamate coordinated oxidovanadium(V) complex derived from the pyridinohydrazone ligand 2′-(2-hydroxy-4-methoxybenzylidene)nicotinohydrazide (H2L), was prepared and characterized by elemental analysis, IR, UV–vis and 1H NMR spectra, and single crystal X-ray diffraction. Thermal analysis of the complex was performed. The V atom is in octahedral coordination. The complex has remarkable inhibitory activity on Jack bean urease with IC50 value of 14.9 μmol·L−1. The interaction mode of the complex with the urease was studied by molecular docking technique.
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