Abstract
One potential method to estimate noninvasive cuffless blood pressure (BP) is through measurement of pulse wave velocity (PWV), which can be characterized by measuring the distance and the transit time of the pulse between two arterial sites. To obtain the pulse waveform, bioimpedance (BI) measurement is a promising approach because it continuously reflects the change in BP through the change in the arterial cross-sectional area. Several studies have investigated BI channels in a vertical direction with electrodes located along the wrist and the finger to calculate PWV and convert to BP; however, the measurement systems were relatively large in size. In order to reduce the total device size for use in a PWV-based BP smartwatch, this study proposes and examines a horizontal BI structure. The BI device is also designed to apply in a very small body area. Our proposed structure is based on two sets of four-electrode BI interface attached around the wrist. The effectiveness of our system and approach is evaluated on 15 human subjects; the PWV values are obtained with various distances between two BI channels to assess the efficacy. The results show that our BI system can monitor pulse rate efficiently in only a 0.5 × 1.75 cm2 area of the body. The correlation of pulse rate from the proposed design against the reference is 0.98 ± 0.07 (p < 0.001). Our structure yields higher detection ratios for PWV measurements of 99.0 ± 2.2%, 99.0 ± 2.1%, and 94.8 ± 3.7% at 1, 2, and 3 cm between two BI channels, respectively. The measured PWVs correlate well with the BP standard device at 0.81 ± 0.08 and 0.84 ± 0.07 with low root-mean-squared-errors at 7.47 ± 2.15 mmHg and 5.17 ± 1.81 mmHg for SBP and DBP, respectively. Our results inform future designs of smart watches capable of measuring blood pressure.
Highlights
High blood pressure (BP) is a principal indicator of several cardiovascular disorders including hypertension
PTTp-p yielded the showed that PTTp-p yielded the highest detection ratio (DR), while PTTf-f achieved the lowest DR for all distances showed DR, thatwhile yielded the highest f-f achieved the lowest for all distances highest offered the lowest for all distances compared to the other detections
Our study proposed a horizontal structure for BI measurements at the wrist to optimize a BP
Summary
High blood pressure (BP) is a principal indicator of several cardiovascular disorders including hypertension. BP monitoring and management are essential to provide more effective care to patients and avoid large financial tolls and reduce the fatality of cardiovascular disorders. There are some existing noninvasive BP measurement devices that can be used at home; they require a cuff or they do not measure BP continuously. In order to develop a wearable device that can measure BP continuously, pulse wave velocity (PWV) and pulse transit time (PTT) have been investigated [1]. PWV is the velocity of the pulse traveling between two arterial sites. By measuring the pulse waveforms at two different sites, PWV values can be obtained using the ratio of the known distance and the pulse transit time (PTT) between two locations. Increasing BP level increases the PWV and decreases PTT values.
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