Abstract
Miller Fisher's syndrome (MFS) commonly presents in the fourth and fifth decades and are rare in people over 70 years. An 85-year-old female with no significant medical history presented with upper extremity anesthesia, ptosis, and unsteady gait. The patient had a history of hypertension and diabetes mellitus. Physical examination showed bilateral total external ophthalmoplegia, areflexia, and cerebellar ataxia. Radiological and laboratory studies were unremarkable. Lumbar puncture showed albuminocytological dissociation. The combined history, physical examination, and lumbar puncture results established a presumptive diagnosis of MFS. Intravenous immunoglobulin was given for 5 days. The patient gradually improved 10 days after the onset of symptoms. Ophthalmoplegia had fully recovered after 6 months. To the best of our knowledge, this case represented the oldest patient with MFS.
Highlights
Miller Fisher’s syndrome (MFS), which was originally described in 1956, is characterized by the triad of external ophthalmoplegia, cerebellar ataxia, and the absence of tendon reflexes.[1]
In 1956 Miller Fisher described three patients of an acute neurological illness characterized by ophthalmoplegia, ataxia, and areflexia.[1]
This illness is referred to as the MFS and is considered an unusual variant of Guillain-Barré syndrome (GBS), because about half of patients who present with MFS progress to GBS
Summary
Miller Fisher’s syndrome (MFS), which was originally described in 1956, is characterized by the triad of external ophthalmoplegia, cerebellar ataxia, and the absence of tendon reflexes.[1]. Miller Fisher’s syndrome (MFS), which was originally described in 1956, is characterized by the triad of external ophthalmoplegia, cerebellar ataxia, and the absence of tendon reflexes.[1] It is considered a variant form of Guillain-Barré syndrome (GBS) because half of patients with MFS eventually experience profound weakness. The syndrome is uncommon in the very elderly.[1] the authors report a case of an elderly patient who has suffered from MFS at 85 years of age.
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