Abstract
A two-step production of [ 18F]F 2 has been developed that exploits the advantageous yield of the 18O(p,n) 18F reaction. A passivated nickel target is first charged with 95.2% enriched 18O 2 and irradiated with 10-MeV protons resulting in a thick-target saturation yield of 150 mCi/μA. The 18F activity is adsorbed on the target walls, permitting quantitative, cryogenic retrieval of the enriched target gas. The target is then refilled with a noble-gas + F 2 mixture and again irradiated, inducing isotopic exchange reactions between the adsorbed 18F and the molecular F 2. After a brief bombardment, this purge gas is suitable for [ 18F]F 2-addition reactions, in particular the synthesis of 18F-labelled 2-deoxy-2-fluoro- D-glucose ([ 18F]-2-FDG). Preliminary studies, in which the noble gas, F 2 concentrations and target temperatures were varied, are discussed.
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