Abstract
We present an interesting case of focal amyloidosis of the left breast which was intermixed with ductal carcinoma in situ (DCIS). On subsequent staging bilateral breast magnetic resonance imaging (MRI), the patient was found to have an additional suspicious enhancing mass with spiculated borders within the left breast. This mass was biopsy proven to represent pleomorphic invasive lobular carcinoma. A pulmonary nodule within the lingula was also noted on the staging bilateral breast MRI and was biopsy proven to represent extranodal Castleman's disease. Therefore, it is believed that our patient had secondary amyloidosis due to Castleman's disease.
Highlights
Amyloidosis is caused by the deposition of insoluble betapleated fibrillar proteins throughout various tissues of the body [1]
Amyloid deposits can have an affinity for calcium, resulting in a mammographic appearance similar to ductal carcinoma in situ (DCIS) or fibrocystic change [1]
Breast amyloidosis typically presents in women from 43 to 86 years of age, with only recent case reports describing their coexistence with breast cancers [1, 2]
Summary
Amyloidosis of the Breast with Multicentric DCIS and Pleomorphic Invasive Lobular Carcinoma in a Patient with Underlying Extranodal Castleman’s Disease. We present an interesting case of focal amyloidosis of the left breast which was intermixed with ductal carcinoma in situ (DCIS). On subsequent staging bilateral breast magnetic resonance imaging (MRI), the patient was found to have an additional suspicious enhancing mass with spiculated borders within the left breast. This mass was biopsy proven to represent pleomorphic invasive lobular carcinoma. A pulmonary nodule within the lingula was noted on the staging bilateral breast MRI and was biopsy proven to represent extranodal Castleman’s disease. It is believed that our patient had secondary amyloidosis due to Castleman’s disease
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
